I redid mine today. I like it.
Main Target Top Mid - Target of Target small to the left of it.
Focus Target Under it.
My Status and Companion above Quickbars and Companion Quickbar extended on the right.
Top Left: Combat stuff
Bottom Left: Guild Chat
Middle Left: Tells, Say, Yell, Emotes... aka Comms
Middle Right: Social (Ops and Party)
Bottom Right: General Spam